Emmy Award-winning actress Katherine Heigl is best known for portraying Dr. Izzie Stevens on ABC's Grey's Anatomy from 2005 to 2010. She began as a child model and eventually transitioned to acting, starring most notably in the 1994 comedy My Father the Hero. Before starring on Grey's, Heigl played Isabel Evans on sci-fi series Roswell from 1999 to 2002. The actress scored her first big screen hit with 2007's Knocked Up and went on to star in the rom-coms 27 Dresses, The Ugly Truth, Life as We Know It and New Year's Eve. Heigl returns to TV on Nov. 17 playing a CIA analyst on NBC's State of Affairs.