Facing a life sentence for a crime he didn't commit, Darien Fawkes volunteers for an experiment that gives him the power of invisibility and is then recruited by a government agency.

Darien and the Agency must capture a Catevari, an escaped patient who can kill with a mere scratch of his fingernails, who seeks revenge on those responsible for his condition.

When an eight-year-old girl is the sole witness to a murder, Darien pretends to be her imaginary friend in the hopes of learning the killer's identity and solving the case.

Darien and Hobbes go after a phony spiritualist who gets a perverse thrill out of convincing his clients to kill themselves.

Darien discovers another patient in The Keeper’s laboratory, a woman with a genetically engineered disease that causes rapid aging, and decides to help her.

After The Official is arrested, a Justice Department employee takes over The Agency to implement his own questionable agenda. Meanwhile, Fawkes and Hobbes attempt to clear their boss' name.