Everything to Know About St. Denis Medical Season 2
The comedy starring Wendi McLendon-Covey and David Alan Grier is back this November with a fresh slate of exciting guests — including two familiar faces from Love Island.
NBC's hilarious hospital-set sitcom St. Denis Medical returns for its sophomore season this November. Whether it's the silly workplace antics, sweet love stories, or cringe-til-you-laugh awkward situations, there's so much to enjoy about the ensemble comedy.
Below, everything we know about Season 2, including who'll be guest-starring as the latest batch of colorful characters to meet Joyce (Wendi McLendon-Covey), Dr. Ron (David Alan Grier), nurse Matt (Mekki Leeper) and the rest of the team.
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When does St. Denis Medical Season 2 premiere?
The series returns with two back-to-back episodes on Monday, November 3 at 8/7c on NBC, streaming next-day on Peacock.
When does St. Denis Medical come back in 2026?
Expect the second half of Season 2 on Monday, January 5, 2026.
St. Denis Medical Season 2's guest stars include some familiar faces in comedy
In addition to Schaal, who'll play a sci-fi fan named Ashley, you may recognize additional visitors in Season 2. Those include Lauren Weedman of Hacks as a nurse who's come out of retirement (for better or for worse), and standup comedian Frankie Quiñones as a security guard named Leslie.
Comedian, improviser and podcaster Lauren Lapkus and Righteous Gemstones alum Tim Baltz will also play an expecting couple in one episode.
Love Island's Ariana Madix and Jeremiah Brown will also guest-star
Love Island Host Ariana Madix will guest star in the role of Dr. Emerson, and Love Island Season 7's Jeremiah Brent will make his acting debut as an Ultimate Frisbee player named Jeff, whose roommate is a St. Denis patient.
The St. Denis cast named what they wanted to see in Season 2
The cast of St. Denis Medical spoke to NBC Insider about their hopes for their characters when the show comes back, and their answers were just perfect. Actor who plays surgeon Dr. Bruce, revealed, “Believe it or not, I really enjoy the actual ‘doctoring’ part of the character. I hope they throw more and more complicated emergencies and surgeries at me. They’re always conscious of making the medical sequences as truthful as possible, and I love learning about that world.”
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As nurse Matt, Mekki Leeper wants to explore the character's crush on fellow nurse Serena (Kahyun Kim). “The Matt and Serena of it all is a little secretive to talk about, so who knows? But I can tell you this, Matt is learning stuff, man,” said Leeper. “In Season 2, he is gonna know how to do, I don’t know three things, maybe four. I look forward to it.”
Superstore alum Kaliko Kauahi plays nurse Val. “I hope Val gets to continue delivering sass and keeping it super real in the ER,” the actress said. Added star Alison Tolman, “I just want to interact with more characters. I want more fun guest stars. I want a mother-in-law to show up... I really want to meet, like, whoever Matt’s weird Craigslist roommate is."
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When it comes to twists, David Alan Grier thinks there’s going to be a lot for Dr. Ron: “Perhaps he gets involved in… overextending himself on Bitcoin, slot machines. I would definitely love to see Dr. Ron take all of his money and just go on an investing spree because his emotions could go up and down like the stock market, literally.”
Wendi McLendon-Covey suggested, “I would like to see [Hospital Admin Joyce] play more of the marimbas...[and to] see what else Joyce has going on and why she is so weird.”
How do I catch up with St. Denis Medical Season 1 before the premiere?
All episodes of St. Denis Medical Season 1 are available to stream on Peacock now.
