Reese's father has days to live, and she is conflicted about saying goodbye to him; Bekker delights in Rhodes' jealousy when she receives flowers from another man; Halstead and Manning's personal issues complicate their treatment of a patient.
Sharon's teenage godson comes to the ED with burns from a house fire; Rhodes and Bekker lose a piece of surgical equipment inside their patient's chest; Manning and Charles must tell a mother that her daughter is genetically male.
The lives of conjoined twins hang in the balance when one twin suffers heart failure, so Rhodes takes matters into his own hands; when an exorcism goes wrong, a possessed woman ends up in the ED in the care of Charles and Reese.
When an infant is kidnapped on his way to the PICU, Chicago Med goes on lockdown and the staff must improvise with limited resources; tension mounts between Manning and Halstead; Reese worries she's like her father.
Rhodes and Bekker are at odds when both of their patients are in dire need of a heart transplant; Manning and Halstead disagree about a mother who wishes to end her son's suffering; Choi must diagnose a woman found unconscious in the waiting room.
Manning and Choi help a homeless teen give birth at a homeless encampment; Halstead is torn when his patient refuses treatment and wants to die; tension is thick between Rhodes and Bekker after they spend the night together.