Goodwin is tasked with enforcing difficult cuts to hospital personnel. Charles' daughter is hospitalized after a car accident. A transplant patient makes a life-changing decision.

Maggie and Frost fight to get a pair of lungs for a young patient. Asher learns whether she can become a surrogate. Ripley and Morris treat a tech billionaire's daughter as she battles leukemia.

The hospital faces a staffing crisis as the nurses stage a sick-out. Archer and Frost bet on who can discharge their patients first. Charles' distrust of a patient complicates his treatment.

Maggie and Goodwin's friendship is tested as tensions rise during the nurses' union's negotiations with the hospital. Ripley and Archer treat a skateboarder struck by an emergency vehicle.

Asher makes a tough call to save a life. Frost and Ripley treat a young boy with a snake bite. Archer gives Naomi a patient to handle on her own on her last day in the E.D.

Charles and Archer treat a heart transplant patient who believes his new heart doesn't want to be in his body. Lenox takes a personal day. Asher discovers a mass on a pregnant woman's ovary.