Jane returns to her roots in South Africa to catch Hank Crawford and stop Roman once and for all; Zapata leaves the CIA and puts the brakes on her romance with Reade; the FBI brings Blake in for questioning.
Jane, Weller and the team must stop Roman from blowing up the United Nations headquarters in New York City in an attempt to assassinate two world leaders; Keaton throws Zapata under the bus at the CIA.
When Patterson gets a hit on an ultraviolet skull tattoo that's on both Jane and Bob Drabkin, the team discovers the assassin who killed Avery's dad; meanwhile, Roman plans destruction while enduring troubling hallucinations. Bill Nye guest stars.
The team decodes the beetle tattoo, which leads them to a deadly weapon that was secretly developed for Hank Crawford, and they must find the weapon's engineer before Roman does; meanwhile, Blake questions Roman's secretive behavior.
Jane and her team must fight for their lives when Roman sends deadly assassins after them; meanwhile, Patterson goes on a date, Reade contends with the O.P.R. inquisitor, Jane and Weller go to dinner, and Zapata attends a funeral.