Following that, Leifer served as writer and supervising producer on HBO's critically acclaimed "The Larry Sanders Show." Leifer then went on to become executive producer and co-creator of "The Ellen Show" on CBS, which was nominated for the People's Choice Award and the GLAAD Award.
Leifer is a regular writer for the Academy Awards and has written material for stars as diverse as Billy Crystal, Chris Rock, Whoopi Goldberg and Ellen DeGeneres.
In 2006, Leifer made her feature directing debut as part of Glamour Magazine's "Reel Moments." Her short film "Blinders," starring Jamie-Lynn Sigler ("The Sopranos") was showcased along with films by Jennifer Aniston and Bryce Dallas Howard, all gracing the independent film festival circuit.
As an actress, Leifer starred in, created and executive produced the WB sitcom "Alright, Already," lauded as one of the "10 Best Shows of the New Season" by the Los Angeles Times and The Washington Post. Leifer has also made guest appearances on "Seinfeld," "The Naked Truth," and "Will and Grace."