Back from Mexico, Connor, Miles, Monroe and Rachel are stunned to find her father's home empty. It doesn't take them long to discover Charlie and Porter are nursing the typhus victims at the quarantine camp. With over a dozen dead, Porter desperately needs azithromycin, and if he doesn't get it soon, the epidemic will rage out of control. Truman is well aware; like it or not, he and Porter are in this thing together. While the men stay back, Rachel sneaks into the camp to offer her help. Getting testy, Truman demands Rachel give up Miles and Monroe, but Porter talks him out of it - for the time being.
Neville meets Julia near the Washington Monument with news: her husband Doyle is holding Jason for suspicion of breaking and entering his office. If Jason breaks, Neville fears he'll give them both up. When Julia makes it clear that all she cares about is Jason's well-being, Neville insists she's their best chance at a rescue. Julia flashes back to two years after the Blackout, when little Jason was dying of starvation. Promising to find food, Neville comes upon a man barbecuing rabbits who refuses to share. Neville whips out his knife, but he's too weak to fight off the man and his friend, who beat him badly.
Porter thinks the epidemic is typhus, but the disease isn't spreading the way it ordinarily would. If only he had time to do some tests... Rachel sends Charlie to collect a blood sample from one of the dead, so she can test it. The result: their typhus was made in a lab, which suggests the Patriots set off the outbreak on purpose. Rachel figures the Patriots must have an antidote, and Porter has an idea of where they might keep such a thing. Rachel gets a message to Miles, who wants to send Connor after the antidote, since no one knows who he is. Connor is furious, so Monroe takes him aside. Rachel may be crazy, but they need Miles' help to win back the Republic - which means they're going to do what he asks.
Aaron wakes up, only to find Grace has disappeared. Suddenly, he turns to face Claudia, who tells him he has to "face it." Assuming Claudia is the nano, Aaron is angry over the real Claudia's death - why did the nano desert him? Nano Claudia assures him that all of his questions will be answered in Lubbock, home to the world's largest concrete cowboy. If he chooses not to go, both he and Priscilla will be in danger. Claiming she's not scared of the nano, Priscilla refuses to go to Lubbock. She's just leaving Aaron behind when a tree nearly falls on top of her.
Before bed, Julia tells Doyle she's been having nightmares because of the office break-in. Just this once, can't he give her more information about the guy who did it? All Doyle will say is they're questioning him. Julia flashes back to the past, when she was patching up Neville after his fight. They've been going about things all wrong. There are plenty of guys stronger than Tom, but not many who are smarter. It's time for them to play to their strengths. Back in the present, Victor is sleeping when Julia sneaks into his office to find Jason's name on a list - and his location in Kenilworth Prison.
Connor, Miles and Monroe sneak into Willoughby under cover of darkness. Miles is stunned to find the Patriots have totally deserted their customary bunker - no antidote. Back at the quarantine camp, Rachel deduces the Patriots are killing off "undesirable" people with their typhus. That's when Porter falls over, the disease's latest victim. When he comes to, he's got a plan. Miles and Monroe kidnap Truman and shoot him up with a dose of typhus. So where's the antidote? In the next leg of the plan, Connor puts on a Patriot uniform and escorts Truman back to his office to retrieve the antidote from his safe. Connor just has enough time to put his gun to Truman's head as soldiers bust into the office for a standoff...
Julia tells Neville her latest plan: she and Victor will be having lunch with Colonel Henderson and his wife tomorrow. She'll leave the door unlocked so Neville can sneak in, "take care" of the colonel and his wife, then have a "little chat" with Doyle. The only thing Julia cares about is getting Jason out alive - whatever it takes. Two years after the Blackout, Julia demonstrates the same mettle: she convinces the two guys who beat Neville to accept sex with her in exchange for food, giving Neville the chance to kill them both. But there's a hitch to her most recent plan: when Neville breaks into the colonel's house, Doyle and his men are waiting with guns aimed at Julia. When she demands the return of Jason, Doyle has the couple separated, promising they'll never see each other again.
The Mathesons and Monroes team up to save Willoughby from a deadly typhus outbreak.