Billie Reed first came to Salem as a professional singer, but her cocaine addiction ruined that opportunity. Billie believed her father was dead and had never known her mother. Her only relative in Salem was her brother Austin. Luckily, Carrie Brady befriended her and gave Billie a place to stay. It took awhile before Billie could get clean and rid her life of past demons.
Eventually, Billie decided to turn her life around and started her own cosmetics company, Countess Wilhelmina. Kate Roberts bought out Countess Wilhelmina to spite Billie. Later that year, Billie befriended Tony DiMera. He bought up 49% of Titan Industries and then brought Billie in to run the Countess Wilhelmina division.
Billie's father Curtis Reed, who had been presumed dead, returned. Curtis was no father of the year. He had gotten Billie addicted to drugs as a young girl and raped her. He was eventually murdered, and Billie was arrested for killing him.
However, Billie refused to tell Bo how she knew Curtis and she made her brother, Austin, keep quiet. Billie thought that if Bo learned the truth, he wouldn't love her. But Bo had fallen in love with Billie and was determined to prove that she was innocent.
Billie and Austin were both shocked when they learned Kate was married to Curtis Reed. Eventually Billie admitted that Curtis was her father. Stefano DiMera had killed Curtis in self-defense and framed Billie. Billie was let go, and Bo told her that he loved her no matter what. Billie and Austin were also reunited with Kate, the mother they thought abandoned them. Kate told them that Curtis had taken them from her, and she believed they had all been killed in a car crash.
Bo and Billie tried to marry on New Year's Day of 1995, but the "Desecrator" struck and a falling chandelier almost killed them. They tried again, but learned that they could not marry if there was any chance that Gina was Hope. In order to help them, Gina signed a paper declaring that Hope was dead, and Bo and Billie were finally married. When Gina was eventually proven to be Hope, Billie realized that Bo had not given his marriage to Hope a fair shot, so she left Salem.
Billie returned a few years later and moved into the Kiriakis Mansion. She began to date Franco, which upset Bo. Bo insisted Franco was dangerous, but Hope accused him of being jealous. Hope grew fed up with Bo's obsession with Franco and told Bo that she couldn't marry him if he still had feelings for Billie.
Billie, meanwhile, discovered that she was pregnant. Bo told her that he would be there for her and the baby. She followed Bo and Hope to New Orleans and then into the bayou where she went into labor. Her baby girl was stillborn. Bo helped Billie get over the loss of their baby; however, he told her that he still loved Hope and wanted to make a life with her. Billie was outraged.
Hope's disdain for Billie only grew over time. When Billie returned to Salem and joined the police force, it only got worse. Billie swore her motives were pure and not meant to create more trouble for Bo and Hope. When Bo helped rescue the victims of the Salem Stalker, whom should he bump into on the island but Billie! Together they helped rescue the others. Upon their return to Salem, Billie made the shocking discovery that their daughter Georgia, who she thought had died in childbirth, was still alive! In fact, she was Chelsea, one of Abby Deveraux's friends. When Chelsea's adoptive parents were killed in a car accident, Billie revealed the truth and had Chelsea move in with her.
Hope was not thrilled by yet another link between Billie and Bo, but she tried to remain supportive. However, when Bo and Hope's son Zack was killed in a car accident, everyone soon learned that Chelsea was responsible. Billie was desperate to protect Chelsea, and Bo was torn between the two women in his life.
Billie started working at Salem University as head of security, where she made it her mission to track down the campus rapist. Unbeknown to her, the man she was looking for, Ford Decker, was already dead. After losing her job, Billie left town when Victor gave her a job at Titan in England. While there, she was in a car accident and had to have her mom, Kate, and her daughter, Chelsea, come to London to help her recover for a short period.
Billie returned to Salem to help her mother as the new co-CEO of Countess Wilhelmina. She is also unveiled to be an ISA agent, moving into the DiMera mansion to spy on EJ DiMera and his father Stefano DiMera. Upon her arrival, Billie immediately stood vigilant by her ex-husband Bo, who was put in a coma. She was later revealed to be working alongside Shane Donovan as part of her ISA mission to take down the DiMera family.