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Dr. Anspaugh is appointed Chief of Staff after his hospital merges with County. Also a member of the hospital board, Anspaugh is County's eminence grise, usually arbitrating most controversies and staffing decisions.
Ray's job performance was impacted by his commitment to his rock band, and his love for Neela created conflict during her marriage. After a drunken fight with Luka and Gates, Ray was hit by a truck and lost his legs.
A talented surgeon with a hot head, Peter has a son with ex Carla who is born deaf. After a relationship with Elizabeth fails, Peter eventually wins custody of Reese and leaves the ER to start a new life with Cleo.
After breaking off an adulterous affair with Benton, Jeanie returns to her husband Al, from who she contracts AIDS. Later Jeanie marries Reggie, adopts HIV+ Carlos and opens two HIV clinics.
Carter comes to County as a med student and stays for 11 years, surviving a stabbing and drug addiction to become chief resident. After the stillbirth of his son, Carter reunites with wife Kem to start over in Africa.
After killing a patient, med student Jin-Mei quits the ER, only to return years later, pregnant with a child she gives up. Needing time to take care of her father, Jin-Mei quits again, to grant his wish for death.
British Elizabeth comes to the ER seeking experience in trauma surgery, and has a hard time staying in the U.S. After an affair with Benton fizzles, Elizabeth finds true love with Greene and gives birth to baby Ella.
Psychologist Dr. Cvetic becomes chronically depressed and hostile. After failing to show up for Thanksgiving dinner with Susan, Cvetic darts into traffic. Later Susan arrives home to find Cvetic has moved out.
A pediatrics intern, Anna initially has friction with Doug. Her relationship with Carter is stymied when she learns of his family fortune. Anna returns to her native Philadelphia to work with her ex, Dr. Max Rocher.
Intern Maggie Doyle works her way up to resident. When Carter shows an interest, she reveals that she's a lesbian. Maggie files a sexual harassment suit against Romano, which eventually leads to her termination.
Talented and exacting, Chief of Surgery Dr. Dubenko enjoys a "friends with benefits" relationship with Skye, until he lashes out at her for refusing to commit. Later, he resigns in protest over the death of a patient.
A tough new pediatric resident, Cleo begins a relationship with Benton, and sticks by him through a rough custody battle for his son Reese. When Cleo finds a new job out of town, Benton quits the ER to join her.
Desk Clerk Randi makes her mark when she punches an annoying patient who sets off a fire alarm. It turns out that Randi is on probation, and has a thing for others like her.
Third year med student Gallant comes to the ER on scholarship from the U.S. Army Reserves. Called up to serve in Iraq, Gallant impulsively marries Neela, and is later killed while on active duty.
Rebellious paramedic Gates becomes an intern. Forgoing a relationship with the mother of his child Sarah, Gates pursues Neela to no avail. When Meg commits suicide, Gates takes custody of Sarah and begins dating Sam.
The wife of Dr. Mark Greene and mother of their daughter Rachel, Jennifer passes the bar, takes a job in Milwaukee and starts an affair with a co-worker. Despite Mark's efforts to save the marriage, Jennifer moves on.
Chief resident Greene loses his first wife to career stress, and his father to lung cancer, but finds love with Elizabeth Corday. Shortly after the birth of their daughter Ella, Greene succumbs to a brain tumor.
ER nurse manager Carol is rushed to the ER after a suicide attempt, perhaps due to a failed romance with Doug. Despite many other relationships, Carol ultimately reunites with Doug after giving birth to their twins.
Arriving for her first day at work in the midst of a blizzard, Dr. Hicks worked as attending for three years, serving as mentor to both Carter and Benton.
Dr. Kayson is Chief of Cardiology and a member of the hospital board. After disagreeing with Susan on the treatment of Myocardial Infarction, Kayson is admitted with the same symptoms, and Susan saves his life.
"By the book" med student Lucy has a brief affair with Carter, which he ends to staunch ethical questions. After coming to terms with her ADHD, Lucy is killed by a schizophrenic patient.
Hailing from Croatia, Luka overcomes his personal tragedy and penchant for casual sex to marry Abby and father baby Joe. Despite Abby's resurgent alcoholism and an affair, Luka remains committed to their marriage.
Although she comes highly recommended, there's something not quite right about Dr. Lee. Despite Jerry's warnings, Mark dates her, until an incident with a patient leads to the discovery that she's not a doctor.
Susan adopts her troubled sister's child, but loses custody. She forgoes a relationship with Greene, later returning to marry nurse Chuck Martin during a drunken Vegas weekend, and give birth to baby Cosmo.
For obstetrics nurse Abby, it's a long way to becoming an ER doctor, with life plagued by her bi-polar mother and brother. Her unexpected pregnancy pushes her relationship with Luka to the next level - marriage.
Resident Malucci occasionally flouts the rules to get things done. When misdiagnosis results in a patient's death, Weaver comes down hard, firing Malucci after finding him having sex with an EMT in an ambulance.
Susan meets flight nurse Chuck in Las Vegas and marries him while drunk. Although the marriage is quickly annulled, the couple has a baby Cosmo, whom Chuck looks after when Susan is promoted to ER Chief.
Following the resignations of Weaver and Luka, Dr. Moretti is moved from the ICU to head up the ER. During a blackout, he has an alcohol-fueled one night stand with Abby. Moretti quits to attend to his troubled son.
Chief of Surgery and ER, Dr. Morgenstern has a heart attack, but returns to work. Not quite up to par, he makes a mistake during surgery and tries to scapegoat Benton, later admitting the truth and resigning.
Slacker Morris achieves the coveted position of Chief Resident due to lack of competition. He begins an effort to win respect and the heart of Dr. Hope Bobeck. After failing his boards, Morris begs Pratt not to tell.
Dr. Pratt's arrogance sometimes gets in the way of his career and love life. When Bettina dumps him, Pratt decides to get serious. Sadly, it comes too late, as he perishes in an explosion in the ambulance bay.
Reserved Londoner Neela overcomes an identity crisis to graduate med school with Abby. Despite her feelings for Ray, Neela marries Gallant, who is killed in Iraq, which prompts a string of unsuccessful relationships.
Insensitive and obnoxious, Dr. Romano is a brilliant surgeon who eventually becomes Chief of Staff. Romano loses his arm when he backs into a helicopter. Later, another chopper falls on him, ending his life.
Despite his womanizing, Doug is a dedicated ER pediatrician. When his attempt to help a patient goes awry, he moves to Seattle. Despite their engagement, Carole gives birth to their twins alone, before joining Doug.
When Dr. Morgenstern resigns after his heart attack, Dr. Swift replaces him.
A struggling single mother of diabetic Alex, Sam endures tragedy at the hands of her ex-husband. After a relationship with Luka fails, Sam enjoys the dating scene until a romance with Gates starts to get serious.
Orthopedic Surgeon Dr. Taglieri, dates Carol after she recovers from her suicide attempt. Although the couple becomes engaged, Tag calls off the wedding on the altar when he realizes Carol doesn't love him enough.
Ambitious and accomplished, Dr. Weaver rises to Chief of Staff, despite her physical disability. After many years, Kerry comes out as a lesbian to the staff, and eventually leaves the ER to become a TV medical reporter.
Neela's new surgical intern Harold tells everyone that he's 25, but he's really 19. Child prodigy Harold offends the surgeons with his superior medical knowledge, while seeking advice on how to lose his virginity.